For making local value of safe_mode to off in plesk follow the below mentioned process:

1) Login to server as root.
2) Go to /var/www/vhosts/domain.com/conf/httpd.include by
cd /var/www/vhosts/domain.com/conf/
3) After that edit httpd.conf
vi httpd.include
Search for safe_mode
4) once got it make to off
Thats it you are done. Now check the php.info by creating it as vi phpinfo.php

<?php phpinfo(); ?>

Save it (Save it under httpdocs)

After change its ownership to user.user

Now browse the domain.com/phpinfo.php

Now the local value of safe_mode will be off


Kind Regards,
Suzanne Jones.